THE FALLON LAB

BRIDGING MECHANISM TO THERAPY

Our lab works at the intersection of basic and translational science.  On the basic science side, our work revolves around a novel signaling pathway that we recently discovered, the MuSK-BMP pathway.  We have linked this pathway to maintaining muscle and synapse integrity and are investigating its role in regulating neural and muscle stem (satellite) cells, myofiber size and synapse integrity. Our work has formed the basis for the formation of Bolden Therapeutics, which is translating these mechanistic insights into drugs for promoting adult hippocampal neurogenesis as a therapy for Alzheimer’s Disease, Major Depressive Disorder, and other neurological and psychiatric diseases.

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